Scientists Edge Closer to HIV Cure

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Researchers at the Peter Doherty Institute for Infection and Immunity in Melbourne have unveiled a breakthrough that could pave the way toward an HIV cure. Their pioneering work uses mRNA technology—similar to what’s used in COVID‑19 vaccines—to expose HIV hiding within white blood cells.

The team developed a novel lipid nanoparticle (dubbed “LNP X”) capable of delivering mRNA into those elusive immune cells, a feat previously thought impossible. Once inside, the mRNA instructs the cells to unmask the hidden virus, enabling it to be targeted by the body’s defence mechanisms.

The results stunned the researchers: experiments repeatedly yielded clear, consistent outcomes—dramatically different from what had come before in their lab.

If successfully combined with therapies that destroy the now-exposed virus, this method could be transformative. Still, it’s early days: additional testing in animal models and extensive safety evaluations in humans will be needed—and only then could efficacy trials begin.

Experts hail the finding as a significant advancement in the field of HIV cure research. While some caution against overoptimism, they agree it marks a major step forward in delivering mRNA to hard-to-reach cells—and could have broader applications beyond HIV, including certain cancers

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